The HPV 9-10 Trial: Early Initiation of HPV Vaccination

Completed · Not applicable

Conditions studied: HPV

In brief

Every year, thousands of Americans die from cancers related to human papillomavirus (HPV). The vast majority of those deaths could be prevented with a safe and effective vaccine, yet many parents choose not have their children vaccinated when it is recommended at age 11 or 12. In this study, we will examine in a randomized trial whether earlier initiation of the vaccine at age 9-10 years will result in less parental refusal and higher rates of full vaccination at younger ages, before early sexual activity begins.

Key facts

Study ID: NCT04722822
Run by: University of Colorado, Denver
People needed: 62272
Starts: 2021-10-04
Expected to finish: 2026-06-01
Last updated by the study team: 2026-07-16

Who can join

Age: 9 and older, up to 13. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Practices in Metro Denver, Colorado and Metro Los Angeles, California (specifically UCLA medical clinics and clinics affiliated with Children's Hospital of Orange County)
Practices that have at least 60% of providers agree to participate
Practices do not currently recommend HPV at 9-10 years.
Practice must have at least 100 eligible patients age 9-13 years

You may not qualify if…

Practices with less than 100 eligible patients age 9-13 years
Practices currently routinely recommend HPV vaccine at 9-10 years.
Practices where less than 60% of providers agree to participate in the study.
Patient Eligibility Criteria
Patient age 9-13 years
Seen at a participating practice in the last 3 years
Due for at least 1 dose of HPV vaccine

Where it is running

University of California at Los Angeles — Los Angeles, California, United States
University of Colorado — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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