Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study

Recruiting now

Conditions studied: Cocaine Use Disorder, Healthy Controls

In brief

The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.

Key facts

Study ID

NCT04721418

Run by

Yale University

People needed

80

Starts

2021-07-20

Expected to finish

2026-06-01

Last updated by the study team

2025-09-11

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 21-60 years
• Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
• For females, a negative serum pregnancy test
• For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
• For HC: Negative urine toxicology

You may not qualify if…

• DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
• A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
• A history of significant and/or uncontrolled medical or neurological illness
• Current use of psychotropic and/or potentially psychoactive prescription medications
• Medical contraindications to MRI procedure

Where it is running

• Connecticut Mental Health Center — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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