JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors

Completed · Phase 1/Phase 2

Conditions studied: Solid Tumor, NSCLC

In brief

To evaluate the safety and tolerability of JAB-3312 administered in investigational regimens in adult participants with advanced solid tumors.

Key facts

Study ID

NCT04720976

Run by

Allist Pharmaceuticals, Inc.

People needed

58

Starts

2021-03-23

Expected to finish

2023-12-19

Last updated by the study team

2025-04-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must have histologically or cytologically confirmed metastatic or locally advanced solid tumor. Some cohorts must meet specific expression or gene mutation where indicated
• Sufficient organ function
• Participants must have at least 1 measurable lesion as defined by RECIST v1.1
• Must be able to provide an archived tumor sample
• ECOG performance status score of 0 or 1.

You may not qualify if…

• History of cancer that is histologically distinct from the cancers under study
• Active or untreated central nervous system (CNS) metastases
• History of pneumonitis or interstitial lung disease (ILD)
• Has active hepatitis B, hepatitis C infection, HIV
• Any severe and/or uncontrolled medical conditions
• LVEF ≤50%
• QTcF >470 msec

Where it is running

• Research Site — Phoenix, Arizona, United States
• Research Site — Scottsdale, Arizona, United States
• Research Site — Los Angeles, California, United States
• Research Site — New Haven, Connecticut, United States
• Research Site — Jacksonville, Florida, United States
• Research Site — Orange City, Florida, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Indianapolis, Indiana, United States
• Research Site — Detroit, Michigan, United States
• Research Site — Rochester, Minnesota, United States
• Research Site — St Louis, Missouri, United States
• Research Site — New York, New York, United States
• Research Site — Oklahoma City, Oklahoma, United States
• Research Site — Houston, Texas, United States
• Research Site — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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