Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

Recruiting now

Conditions studied: Frailty, Sarcopenia

In brief

Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.

Key facts

Study ID

NCT04717869

Run by

University of California, Los Angeles

People needed

250

Starts

2023-09-22

Expected to finish

2026-07-01

Last updated by the study team

2026-01-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
• ICU stay longer than 24 hours

You may not qualify if…

• Patients with muscular or mitochondrial diseases affecting muscle quality or mass
• Preexisting paralysis
• Absence of lower limbs
• Ongoing discussions about goals of care
• Transfers from a skilled nursing facility
• Children under the age of 18

Where it is running

• Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine — Los Angeles, California, United States (enrolling)

Full record on ClinicalTrials.gov

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