Telehealth Based Intervention to Improve Functional Capacity in Survivors of Childhood Cancer With Significantly Limited Exercise Tolerance

Completed · Not applicable

Conditions studied: Childhood Cancer, Mobility Limitation

In brief

The participants are asked to take part in this clinical trial, a type of research study. The participants are SJLIFE study participants and may have a hard time exercising (exercise intolerance) due to side effects of cancer treatment received as a child.This study is being done to determine if a personalized exercise plan will help childhood cancer survivors who have exercise intolerance become more active. Primary Objectives: To achieve the goal of this study, we propose the following three Objectives: Primary Objective 1: To determine the efficacy of an individually tailored, home-delivered aerobic and strengthening intervention to improve exercise capacity in survivors of childhood cancer with exercise intolerance (peak oxygen uptake (peak VO2) \<85% of age and sex predicted). Primary Objective 2: To determine the effects of an individually tailored, home-delivered aerobic and strengthening intervention on measures of cardiac, pulmonary, musculoskeletal, and neurosensory function in survivors of childhood cancer with exercise intolerance. Primary Objective 3: To determine the effects of an individually tailored, home-delivered aerobic and strengthening intervention on emotional health, participation in family and community activities, quality of life, and cognitive function in survivors of childhood cancer with exercise intolerance.

Key facts

Study ID

NCT04714840

Run by

St. Jude Children's Research Hospital

People needed

181

Starts

2021-02-08

Expected to finish

2026-02-23

Last updated by the study team

2026-04-01

Who can join

Age: 18 and older, up to 39. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Between 18.00 and 39.99 years of age at the time of enrollment
• SJLIFE participant
• Peak VO2 <85% predicted
• Verbalizes understanding of directions for use of ZOOM on the study provided iPad and heart rate monitor
• Clearance for participation in exercise by a study physician
• Internet access

You may not qualify if…

• Enrolled in a formal exercise intervention
• Self-report of engaging in > 150 minutes/week of moderate physical activity
• Currently pregnant (assess by urine pregnancy test)
• Significant psychological distress (e.g. suicidal ideation)
• Requires immediate medical intervention (e.g. angina, decompensated heart failure)
• Research Participant Recruitment and Screening

Where it is running

• St. Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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