Bone Density and Vascular Calcifications Evolution After Renal Transplant

Recruiting now

Conditions studied: Kidney Transplant; Complications, Bone Loss

In brief

The investigators project is based on: * Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA); * The non-invasive detection of vascular calcifications (by abdominal CT scanner) and bone abnormalities associated with kidney transplantation, as well as the analysis of evolution over time; * Longitudinal evaluation of nephrological clinical parameters (glomerular filtration rate, number and type of rejections, immunosuppressive medications) as well as biological and urinary parameters of mineral metabolism (parathormone, sclerostin, bone alkaline phosphatase) depending on the type and severity of bone abnormalities; * The evaluation of these nephrological clinical parameters and of the biological parameters of mineral metabolism depending on the extent and evolution of vascular calcifications but also on bone morphology; * The study of possible relationships between bone mass and muscle mass (and functioning)

Key facts

Study ID

NCT04713774

Run by

University of Liege

People needed

50

Starts

2020-09-01

Expected to finish

2026-12-13

Last updated by the study team

2024-12-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years old
• Recent kidney transplant patients (<3 months)
• Medical history available
• Biological parameters of the past year available

You may not qualify if…

• Treatment with bisphosphonate, RANKL inhibitor or SERM with bone action in the last 3 months before the transplant
• Multiple organ transplant patients

Where it is running

• Centre Hospitalier Universitaire de Liège — Liège, Belgium (enrolling)

Full record on ClinicalTrials.gov

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