Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

Recruiting now · Not applicable

Conditions studied: Pulmonary Embolism, Hematopoiesis

In brief

The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.

Key facts

Study ID

NCT04711746

Run by

Centre Hospitalier Universitaire, Amiens

People needed

544

Starts

2021-02-01

Expected to finish

2026-01-01

Last updated by the study team

2025-05-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening.
• For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.

You may not qualify if…

• Age superior to 65 years old,
• Active cancer

Where it is running

• CHU Amiens — Amiens, France (enrolling)

Full record on ClinicalTrials.gov

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