Screening for Colonization With Resistant Enterobacterales in Neutropenic Patients With Hematologic Malignancies
Completed
Conditions studied: Hematologic Malignancy, Leukemia, Acute, Neutropenia, Bloodstream Infection
In brief
This is a prospective, observational cohort study to assess the frequency with which neutropenic patients with hematologic malignancies and hematopoietic cell transplant (HCT) recipients are colonized with fluoroquinolone-resistant Enterobacterales (FQRE) and the clinical impact of FQRE colonization.
Key facts
- Study ID
- NCT04710212
- Run by
- Duke University
- People needed
- 168
- Starts
- 2021-03-12
- Expected to finish
- 2022-02-28
- Last updated by the study team
- 2022-04-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Ability to provide informed consent
- Male or female ≥18 years of age
- Receiving intensive induction chemotherapy for acute leukemia or undergoing HCT
- Receive fluoroquinolone prophylaxis during neutropenia
You may not qualify if…
- Expected to have <7 days of neutropenia (absolute neutrophil count ≤500 cells/μL) after receipt of chemotherapy (a) (acute leukemia cohort only)
- First swab collected ≥5 days after onset of chemotherapy
- First swab collected after the day of transplant (HCT cohort only)
- Acute promyelocytic leukemia
- Receiving chimeric antigen receptor (CAR)-T-cell therapy
- Pregnant women as determined by clinician
Where it is running
- University of California San Fransisco Medical Center — San Francisco, California, United States
- Hackensack Meridian Health — Nutley, New Jersey, United States
- Mount Sinai Hospital — New York, New York, United States
- University of North Carolina Chapel Hill — Chapel Hill, North Carolina, United States
- Oregon Health and Science University — Portland, Oregon, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.