A Drug Interaction Study of Danicopan

Completed · Phase 1

Conditions studied: Healthy

In brief

This was a 3-part study (Part 1, Part 2, Part 3) with each part being an open-label, fixed sequence, 2-period study in healthy adult participants.

Key facts

Study ID

NCT04709094

Run by

Alexion Pharmaceuticals, Inc.

People needed

52

Starts

2019-07-28

Expected to finish

2020-04-17

Last updated by the study team

2021-01-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Parts 1 and 2: adult males or females between 18 and 55 years of age, inclusive, at screening. Part 3: adult females between 18 and 65 years of age, inclusive, at screening.
• Body mass index in the range of 18.0 to 32.0 kilograms (kg)/meter squared, inclusive, with a minimum body weight of 50.0 kg at screening.
• No clinically significant history or presence of electrocardiogram abnormalities at screening.
• Non-sterile male participants must agree to abstinence or use a highly effective method of contraception.
• Female participants must be of non-childbearing potential and need not employ a method of contraception.
• Part 1 only: Participant has a negative fecal occult blood test at screening.

You may not qualify if…

• Clinically significant laboratory abnormalities.
• History of any medical or psychiatric condition or disease that might limit the participant's ability to complete or participate in this clinical study, confound the results of the study, or pose an additional risk to the participant by their participation in the study.
• History or presence of drug or alcohol abuse within previous 2 years, current tobacco/nicotine user, or positive for alcohol and/or drug screen at screening or Day -1 of Period 1.
• History or presence of clinically significant seizures, head injury, or head trauma.
• History of procedures that could alter absorption or excretion of orally administered drugs.
• History of meningococcal infection, or a first-degree relative with a history of meningococcal infection.
• A history of significant multiple and/or severe allergies or has had an anaphylactic reaction or significant intolerability to prescription or non-prescription drugs.
• Body temperature ≥ 38.0°Celsius at screening or prior to first dosing in Period 1 or history of febrile illness, or other evidence of infection, within 14 days prior to first dosing.
• Donation of whole blood from 3 months prior to first dosing, or of plasma from 30 days before first dosing, or receipt of blood products within 6 months prior to first dosing.
• Participation in any other investigational study drug trial in which receipt of an investigational study drug occurred within 5 half-lives (if known) or 30 days before first dosing, whichever is longer.
• Part 1 Only:
• History or presence of any of the following, with clinical significance:
• bleeding disorder(s), including relevant familial history;
• anemia (for example, history of temporary anemia during pregnancy is acceptable);
• thromboembolic disease;
• bleeding in the gastrointestinal tract or central nervous system.
• Has active severe gingivitis.
• Clinically significant illness, clinically significant surgery, including tooth extraction, trauma, or head injury, within 28 days before Day 1 of Period 1.
• Participant is employed or actively involved in any circumstance that would place them at increased risk of hemorrhage during the study (for example, contact sports, strenuous or unaccustomed weight lifting, running, bicycling).
• Participant has taken large daily doses of vitamin K (> 25 micrograms/daily) and/or has a diet rich in vitamin K 14 days prior to the first dosing.
• Part 2 Only:
• Any significant finding on the Columbia-suicide severity rating scale.
• History or presence of any of the following, with clinical significance:
• bulimia or anorexia nervosa;
• hypertension;

Where it is running

• Clinical Study Site — Tempe, Arizona, United States

Full record on ClinicalTrials.gov

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