Adaptive Immune Response in Visceral and Subcutaneous Fat: Role in Human Insulin Resistance

Enrolling by invitation

Conditions studied: Insulin Resistance, Insulin Sensitivity, Obesity, Inflammation

In brief

The proposed study is designed to test the hypothesis that in human obesity, the balance of pro- and anti-inflammatory T cells in fat tissue is in fact related to macrophage phenotype and insulin resistance, and how it is related. This study is needed to confirm whether conclusions based on studies of visceral adipose tissue in mice are indeed applicable to humans. We also want to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals.

Key facts

Study ID

NCT04708535

Run by

Stanford University

People needed

50

Starts

2017-08-01

Expected to finish

2026-08-01

Last updated by the study team

2026-05-13

Who can join

Age: 30 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current patients of Stanford Healthcare, Bariatric Surgery Clinic, scheduled to undergo bariatric surgery (sleeve or RYGB)
• BMI 30-55kg/m2
• 30-65 years of age
• good general health, no major organ disease
• non-diabetic by current American Diabetes Association (ADA) criteria (fasting glucose <126mg/dl)

You may not qualify if…

• Subjects with any clinical or biochemical evidence of significant anemia, gastrointestinal, cardiac, hepatic or renal disease will be excluded.
• Subjects with other medical problems may participate as long as the problems are stable.
• Subjects with active psychiatric disorders or past history of bariatric surgery
• Pregnant or lactating women will also be excluded from the study, due to possible risk to the fetus or infant.

Where it is running

• Stanford University — Stanford, California, United States

Full record on ClinicalTrials.gov

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