Vascular Endothelial Growth Factor (VEGF) Levels in Retinal Vein Occlusion (RVO) During Anti-VEGF Treatment
Stopped early · Phase 4
Conditions studied: Retinal Vein Occlusion
In brief
The purpose of this study is to treat patients with retinal vein occlusion with standard of care anti-vascular endothelial growth factor therapy and to correlate levels of vascular endothelial growth factor in the anterior chamber fluid of the eye. This study will evaluate if measuring the vascular endothelial growth factor will help predict the timing of when anti-vascular endothelial growth factor therapy will be needed.
Key facts
- Study ID
- NCT04707625
- Run by
- Wake Forest University Health Sciences
- People needed
- 17
- Starts
- 2021-10-06
- Expected to finish
- 2023-12-18
- Last updated by the study team
- 2025-02-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Willingness and ability to provide written informed consent.
- Diagnosis of Retinal Vein Occlusion with macular edema and central foveal thickness of greater than or equal to 300 microns confirmed by intravenous fluorescein angiography and Optical Coherence Tomography
- Visual Acuity between 20/25 and 5/200
You may not qualify if…
- Bilateral Retinal Vein Occlusion
- Vision worse than 5/200 in study eye
- History of myocardial infarction, ischemia, or cerebrovascular accident within 6 weeks of screening
- Concurrent Proliferative Diabetic Retinopathy and/or Maculopathy
- Concurrent Exudative Age-related Macular Degeneration
- Concurrent optic neuropathy with the presence of an afferent pupillary defect
- Previous vitrectomy in the study eye
- Currently pregnant or planning to become pregnant during the duration of the study. Women currently breastfeeding are also excluded.
- Previous treatment for retinal vein occlusion in the study eye
- Any current medical condition which, in the opinion of the investigator is considered to be uncontrolled
- History of allergy or hypersensitivity to study treatment, fluorescein, or any study procedure and treatment related ingredients (e.g. topical anesthetics, betadine, etc.)
Where it is running
- Wake Forest Health Sciences — Winston-Salem, North Carolina, United States
Full record on ClinicalTrials.gov
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