Precision-Based Genomics in Prostate Cancer

Recruiting now

Conditions studied: Prostate Cancer

In brief

Background: Prostate cancer is the most common cancer and the second leading cause of death in males in the United States. Researchers want to find additional gene mutations that may increase a man s risk for prostate cancer and may affect how aggressive the disease is. Objective: To look at gene mutations in men with prostate cancer as well as the course of their disease to better understand how gene mutations relate to the way the cancer progresses and responds to treatment. Eligibility: Adult males 18 and older with prostate cancer who have at least one of the gene mutations researchers want to study and/or have been treated for their cancer and have had complete elimination of their cancer or stable disease for a long time. Design: Participants will be screened with a review of their medical records. Their gene test results will be reviewed, if available. They will be asked questions over the phone or in person. Participants do not need to visit the NIH for this study. But if they visit NIH for another study, their data and test results will be collected. They may give blood and urine samples. They may give leftover tumor samples. These samples will be used to study their genes. Participants who do not come to NIH on regular basis will be contacted every 6 months by phone or e-mail. They will be asked questions about their health. Data from their medical records will be collected. Participants will have testosterone and prostate-specific antigen (PSA) tests. Participants may be invited to NIH to give blood samples for research. Participants on this study will be followed for life.

Key facts

Study ID

NCT04706663

Run by

National Cancer Institute (NCI)

People needed

2000

Starts

2021-09-14

Expected to finish

2030-06-30

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 120. Sex: male. Healthy volunteers: not accepted.

You may not qualify if…

• None

Where it is running

• University of California San Diego — La Jolla, California, United States (enrolling)
• University of California San Francisco — San Francisco, California, United States (enrolling)
• NorthShore University HealthSystem — Evanston, Illinois, United States (enrolling)
• National Institutes of Health Clinical Center — Bethesda, Maryland, United States (enrolling)
• Dana Farber Cancer Institute, Boston, MA — Boston, Massachusetts, United States (enrolling)
• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
• University of Washington — Seattle, Washington, United States (enrolling)
• Mount Sinai Hospital — New York, New York, United States
• Weill Cornell Medicine — New York, New York, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Oregon Health Sciences University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.