Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases
Recruiting now
Conditions studied: Multiple System Atrophy, Parkinson Disease, Progressive Supranuclear Palsy, Motor Neuron Disease, Neurodegenerative Diseases
In brief
This is a non-interventional observational study designed to systematically record the results of routine laryngeal examinations and specific characteristics of dysphagia in patients with neurodegenerative disorders. The results of a fiberoptic / flexible endoscopic evaluation of swallowing (FEES) while performing a structured task protocol will be recorded. If available, laryngeal electromyography (EMG) results will also be recorded. In addition to the examination results, demographic and disease-specific data are collected, and two questionnaires, the Swallowing Disturbance Questionnaire for Parkinson's Disease (SDQ-PD) and the swallowing specific Quality Of Life Questionnaire (SWALQOL), are administered.
Key facts
- Study ID
- NCT04706234
- Run by
- Kliniken Beelitz GmbH
- People needed
- 350
- Starts
- 2017-09-01
- Expected to finish
- 2028-07-31
- Last updated by the study team
- 2025-04-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- diagnosis of probable or possible multiple system atrophy according to current consensus criteria (Gilman et al. 2008) or
- diagnosis of probable or possible PSP according to the the Movement Disorders Society (MDS) diagnostic criteria (Höglinger et al. 2017) or
- diagnosis of Parkinson's disease according to the MDS diagnostic criteria (Postuma et al 2015)
- Hoehn and Yahr Stage within the range of I-V or
- diagnosis of motor neurone disease or
- diagnosis of a neurodegenerative disease other than specified above
- AND underwent laryngopharyngeal assessment according to the systematic task protocol during FEES (Warnecke et al. 2019).
You may not qualify if…
- Patients who do not sign the consent form
Where it is running
- Department of Neurology and Department of ENT, Medical University Innsbruck — Innsbruck, Tyrol, Austria (enrolling)
- Department of Neurology, Medical University of Ulm — Ulm, Baden-Wurttemberg, Germany (enrolling)
- Movement Disorders Hospital - Kliniken Beelitz — Beelitz-Heilstätten, Brandenburg, Germany (enrolling)
- Department of Neurology, Medical School Hannover — Hanover, Lower Saxony, Germany (enrolling)
- Department of Neurology, University Hospital Münster — Münster, North Rhine-Westphalia, Germany (enrolling)
- Department of Neurology, University Hospital Carl Gustav Carus — Dresden, Saxony, Germany (enrolling)
- Department of Neueology Asklepios Klinik Stadtroda — Stadtroda, Thuringia, Germany (enrolling)
- Asklepios Fachklinikum Stadtroda — Stadtroda, Thuringia, Germany (enrolling)
- Asklepios Klinik Barmbek — Hamburg, Germany (enrolling)
- Department of Neurology Asklepios Klinik Barmbek — Hamburg, Germany (enrolling)
- Department of Neurology, Movement Disorders Unit, Medical Center Tel Aviv — Tel Aviv, Israel (enrolling)
- IRCCS Istituto delle Scienze Neurologiche, Azienda USL di Bologna — Bologna, Italy (enrolling)
- Department of Neurology, Gifu University Graduate School of Medicine — Gifu, Japan (enrolling)
- Department of Neurology, Medical University Warsaw — Warsaw, Poland (enrolling)
- Department of Neurology SNUCM — Seoul, South Korea (enrolling)
- Unidad de Parkinson y Trastornos del Movimiento Instituto Clínic de Neurociencias, Hospital Clinic de Barcelona — Barcelona, Catalonia, Spain (enrolling)
Full record on ClinicalTrials.gov
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