Pregabalin vs. Gabapentin on Reducing Opioid Usage

Completed · Phase 4

Conditions studied: Analgesics, Gabapentin, Injuries, Narcotics, Pain, Trauma

In brief

This is a single-center, randomized, open-label, Phase 4 clinical trial investigating the efficacy of multiple-dose administrations of Pregabalin or Gabapentin in combination with traditional opioid pain medications to decrease the amount of opioid pain medication usage in single-system orthopedic trauma patients.

Key facts

Study ID

NCT04705480

Run by

CAMC Health System

People needed

109

Starts

2021-04-12

Expected to finish

2024-12-13

Last updated by the study team

2026-01-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Nurse Practitioner service admissions
• 18 years of age or older
• Patients enrolled within 36 hours of admission
• Anticipated duration of hospitalization > 24 hours from time of consent
• Active order(s) for opioids in place at the time of enrollment

You may not qualify if…

• Clinician discretion based on patient care management
• Intubated patients
• Patients with epidural
• Patients with pregabalin/gabapentin as home medications
• Patients receiving pregabalin/gabapentin upon admission
• Traumatic brain injury patients
• CrCl<30ml/min or on HD
• Unable to take enteral medications
• On Patient Controlled Analgesia (PCA)
• Patients with complicated wound closure
• History of epilepsy
• Documented history of substance use disorder

Where it is running

• Charleston Area Medical Center"s Level 1 Trauma Center — Charleston, West Virginia, United States

Full record on ClinicalTrials.gov

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