Early Use of Cryoprecipitate With Major Hemorrhage Protocol (MHP) Activation

Completed · Phase 3

Conditions studied: Trauma Injury

In brief

The purpose of this trial is to compare standard of care (SOC) massive transfusion protocol to SOC massive transfusion protocol plus early use of cryoprecipitate (within 90 minutes of emergency department arrival).

Key facts

Study ID

NCT04704869

Run by

Bryan Cotton

People needed

1604

Starts

2017-01-01

Expected to finish

2022-11-01

Last updated by the study team

2025-01-14

Who can join

Age: 16 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The patient is judged to be an adult (according to local practice, e.g. 16 years or older in UK) and has sustained severe traumatic injury. In the event the age is unknown, estimated body weight ≥50 kg.
• The patient is deemed by the attending clinician to have on-going active hemorrhage AND REQUIRES Activation of the local major hemorrhage protocol for management of severe blood loss AND HAS STARTED or HAS RECEIVED at least one unit of any blood component

You may not qualify if…

• The patient has been transferred from another hospital
• The trauma team leader deems the injuries incompatible with life
• More than 3 hours have elapsed from the time of injury
• Prisoner (as defined as someone admitted from a correctional facility)
• Known "Do Not Resuscitate" orders
• Enrolled in a concurrent ongoing interventional, randomized clinical trial
• Patients who wear "opt out" bracelet for study
• Obvious pregnancy
• Severely burned

Where it is running

• The University of Texas Health Science Center at Houston — Houston, Texas, United States
• Queen Elizabeth Hospital — Birmingham, United Kingdom
• Royal Sussex County Hospital — Brighton, United Kingdom
• Southmead Hospital — Bristol, United Kingdom
• Addenbrooke's Hospital — Cambridge, United Kingdom
• University Hospital of Wales — Cardiff, United Kingdom
• University Hospital of Coventry and Warwickshire — Coventry, United Kingdom
• Hull Royal Infirmary — Hull, United Kingdom
• Leeds General Infirmary — Leeds, United Kingdom
• University Hospital Aintree — Liverpool, United Kingdom
• Royal London Hospital — London, United Kingdom
• King's College Hospital — London, United Kingdom
• St. George's Hospital — London, United Kingdom
• St. Mary's Hospital — London, United Kingdom
• Manchester Royal Infirmary — Manchester, United Kingdom
• Salford Royal Hospital — Manchester, United Kingdom
• James Cook University Hospital — Middlesbrough, United Kingdom
• Royal Victoria Infirmary — Newcastle upon Tyne, United Kingdom
• Queens Medical Centre — Nottingham, United Kingdom
• John Radcliffe Hospital — Oxford, United Kingdom
• Derriford Hospital — Plymouth, United Kingdom
• Royal Preston Hospital — Preston, United Kingdom
• Northern General Hospital — Sheffield, United Kingdom
• University Hospital Southampton — Southampton, United Kingdom
• University Hospital of North Staffordshire — Stoke-on-Trent, United Kingdom

Full record on ClinicalTrials.gov

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