The Therapy of Large Endometrioma

Recruiting now

Conditions studied: Endometrioma, Endometriosis Ovary

In brief

Endometrioma's prevalence is between 23 and 55%. It causes pelvic pain, decrease fertility and ovarian reserve. Currently, there's no recommendation about large endometrioma's treatment and there's no information on the best treatment to limit recurrences, preserve fertility and ovarian reserve. In Lille university hospital, simple laparoscopic drainage associated with hormonal therapy is practiced to reduce the risk of cystectomy. This protocol will be evaluated with an observational and prospective study, including women of childbearing age having endometrioma measuring 6 cm or above. The aim of this study is to assess if cyst drainage associated with GnRH agonist, could decrease endometrioma recurrences, deleterious effect on ovarian reserve and evaluate impact on anti-mullerian hormone

Key facts

Study ID: NCT04704115
Run by: University Hospital, Lille
People needed: 62
Starts: 2021-01-21
Expected to finish: 2026-12-01
Last updated by the study team: 2025-12-23

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Endometrioma size ≥ 6cm determined by MRI or ultrasonography
Women with isolated endometrioma or other extraovarian endometriosis: peritoneal, infiltrating endometriotic lesions and adenomyosis.
Cyst single or bilateral

You may not qualify if…

Cyst with radiographic or macroscopic in laparoscopy atypia
Pregnancy
Patient with contraindication to GnRH agonist (Enantone® 3,75 mg et Decapeptyl® 3 mg)
Patient with contraindication to laparoscopy
Patient with contraindication to general anesthesia
Subject refusing to participate in the study

Where it is running

Hop Jeanne de Flandre Chu Lille — Lisle-sur-Tarn, France (enrolling)

Full record on ClinicalTrials.gov

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