Reinstatement of Context During Sleep and Its Subsequent Effect on Memory: an fMRI Study

Completed · Not applicable

Conditions studied: Sleep, Consolidation

In brief

Memory benefits from sleep and these benefits are putatively achieved through reactivation of the neural memory trace during sleep. Studies examining the effects of reactivation commonly focus on single, isolated items - but real-life memories never exist in a vacuum. Individual memories are bound to the context (e.g., the location, time and state of mind in which they are encoded) and this context is later reinstated to recall the details related to the memory. The question of how context participated in the process of sleep reactivation has never been directly examined. This experiment will monitor brain activity during memory encoding, sleep and finally retrieval to investigate the role context plays in sleep-related memory consolidation. Monitoring will be done using functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) recordings. Participants will go through a series of training trials, in which they will have to learn to associate several small images of items or animals with a larger image of scenes - and also learn the spatial location of these smaller images on the screen. The order of the presented images and the scenes in which they are embedded will remain constant throughout training, creating a solid, consistent temporal context in which item memories will be embedded. After training, participants will receive a 90 minute nap opportunity, during which the sounds associated with specific images will be unobtrusively presented. I expect memory for the spatial location of the cued images to improve. Importantly, I hypothesize that this effect will carry over to other items associated with the same scene (i.e., embedded in the same context) and that the temporal order in which the images were learned will govern this effect. I will use the EEG and fMRI data to estimate, on the basis of neuronal pattern activity, the level of contextual reinstatement and will build on these data, in combination with the behavioral results, to model the level of contextual involvement during sleep. These results could pave the way towards a unified theory of sleep's role in memory consolidation, which would encompass computational models of context and memory as well.

Key facts

Study ID

NCT04702724

Run by

Northwestern University

People needed

26

Starts

2021-05-10

Expected to finish

2022-06-30

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Participants with a history of neurological disorders or of sleep disorders will be excluded.
• Participants who do not believe they would be able to fall asleep in the lab will be excluded.
• Participants with a history of metalworking, an injury with shrapnel or metal slivers, a cardiac pacemaker implantation, a neuro-stimulator implantation, or claustrophobia will be excluded. Participants who are or suspect they may be pregnant will not be excluded.

Where it is running

• Center for Translational Imaging - Northwestern University — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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