Immuno-inflammatory Profile and Response to Ischemic Stroke Reperfusion Therapies (IMMUNOSTROKE)
Starting soon · Not applicable
Conditions studied: Stroke, Ischemic Stroke
In brief
IMMUNOSTROKE study aims to describe the immuno-inflammatory and thrombo-inflammatory profiles during the course of AIC management by reperfusion treatment and to monitor changes in these different parameters over time. Post-hoc analyses will make it possible to correlate the immuno-inflammatory and thrombo-inflammatory profiles and their evolution with the clinical outcome in terms of post-AIC functional and cognitive disability.
Key facts
- Study ID
- NCT04701619
- Run by
- Fondation Ophtalmologique Adolphe de Rothschild
- People needed
- 300
- Starts
- 2026-09-15
- Expected to finish
- 2028-05-15
- Last updated by the study team
- 2026-01-20
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient over 18 years of age
- Presenting with an ACS for which reperfusion therapy is indicated according to European and North American recommendations (IV thrombolysis or mechanical thrombectomy or a combination of both)
- Having received informed information about the study and having signed a consent form to participate in the study (if this is not possible: information and consent from a trusted person or family member if present; emergency inclusion if absent)
- Affiliated with or beneficiary of a social security system
You may not qualify if…
- Contraindication to performing a brain MRI (claustrophobia, pacemaker, or other implantable device contraindicating the performance of an MRI)
- Intracranial hemorrhage associated with AIC on initial imaging
- Immunosuppressive treatment or corticosteroid therapy at patient admission
- Pre-existing neurological disability limiting neurological assessment at 3 months (mRS>2 at admission)
- Known and diagnosed dementia pre-existing at the time of the AIC
- Absolute or relative contraindication to the injection of gadolinium (history of true allergic reaction or intolerance to gadobutrol, renal failure with creatinine clearance <15mL/min, pregnant or breastfeeding women)
- Patient treated by another institution and referred solely for mechanical thrombectomy
- Patient benefiting from legal protection measures
Full record on ClinicalTrials.gov
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