Synuclein-One Study

Completed

Conditions studied: Parkinson Disease, Multiple System Atrophy, Dementia With Lewy Bodies, Pure Autonomic Failure

In brief

The Synuclein-One Study will be evaluating α-synuclein in patients with Parkinson's disease, Multiple System Atrophy, Dementia with Lewy bodies and Pure Autonomic Failure. Using a simple diagnostic test will improve clinical accuracy in diagnosing, earlier diagnosis, and distinguish between neurodegenerative diseases.

Key facts

Study ID

NCT04700722

Run by

CND Life Sciences

People needed

428

Starts

2021-01-04

Expected to finish

2023-11-08

Last updated by the study team

2024-01-03

Who can join

Age: 40 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female between 40-99 years of age
• Prior clinical diagnosis of Parkinson's disease, Multiple System Atrophy, Dementia with Lewy bodies or Pure Autonomic Failure
• Health Subjects, no history of clinical or symptoms suggestive with synucleinopathy

You may not qualify if…

• Clinical evidence of severe vascular disease (history of ulceration, poor wound healing, vascular claudication)
• Clinically active coronary artery or cerebrovascular disease
• Current smoker or alcoholism
• History of allergic reaction to local anesthesia for skin biopsies
• Use of blood thinners (aspirin or Plavix alone is allowed)
• Significantly impaired wound healing or history of scarring or keloid formation
• Healthy individuals or individuals with synucleinopathy is disease may be explained by other causes: recent history of encephalitis, Cortical dementia of Alzheimer's type, Whipple's disease, toxin exposure, repeated head injury and stepwise disease progression suggestive of vascular etiology

Where it is running

• MD First Research — Chandler, Arizona, United States
• CND Life Sciences — Phoenix, Arizona, United States
• Movement Disorders Center of Arizona — Scottsdale, Arizona, United States
• The Neuro Center — Carlsbad, California, United States
• Providence St. John's Health — Santa Monica, California, United States
• Rocky Mountain Movement Disorders Center, PC — Englewood, Colorado, United States
• Aventura Neurology — Aventura, Florida, United States
• Parkinson's Disease and Movement Disorders Center of Boca Raton — Boca Raton, Florida, United States
• UF College of Medicine — Gainesville, Florida, United States
• Parkinson's Disease Treatment Center SWFL — Port Charlotte, Florida, United States
• NorthShore University Health System — Evanston, Illinois, United States
• Boston Medical Center — Boston, Massachusetts, United States
• Beth Israel Lahey Health — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States
• NYU Medical Center — New York, New York, United States
• SouthShore Neurologic — Patchogue, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• Providence Brain & Spine Institute — Portland, Oregon, United States
• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• UTSouthwestern — Dallas, Texas, United States
• Texas Movement Disorders Specialists — Georgetown, Texas, United States
• Evergreen Health — Kirkland, Washington, United States
• Swedish Neuroscience Research — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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