Returning Research Results That Indicate Risk of Alzheimer Disease Dementia to Healthy Participants in Longitudinal Studies

Running, not enrolling · Not applicable

Conditions studied: Alzheimer Disease, Dementia of Alzheimer Type

In brief

This is a study to evaluate the impact of returning research results that indicate a five-year risk estimate of Alzheimer disease dementia to participants without memory or thinking problems of the Knight Alzheimer Disease Research Center at Washington University in St. Louis.

Key facts

Study ID

NCT04699786

Run by

Washington University School of Medicine

People needed

450

Starts

2021-02-19

Expected to finish

2026-06-01

Last updated by the study team

2026-03-10

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current Knight ADRC participants who had their clinical assessment in the previous year.
• Minimum age of 65 years old
• Participant must be classified as cognitively normal (CDR® = 0) at their last clinical assessment.
• Participant has either recent research brain MRI and amyloid PET scan results, or recent plasma amyloid measurements (ideally within the past two years, but up to five years will be acceptable due to COVID-19-related delays).
• Participant has genetic research results available including APOE status.
• Participant is currently consented to be contacted for other research opportunities through the Knight ADRC.

You may not qualify if…

• There are no exclusion criteria, other than not meeting all of the inclusion criteria listed above.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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