LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

Recruiting now · Not applicable

Conditions studied: Glioma, Glioblastoma, Brain Tumor

In brief

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

Key facts

Study ID

NCT04699773

Run by

University of Maryland, Baltimore

People needed

32

Starts

2021-02-20

Expected to finish

2027-12-01

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with radiographic evidence of suggestive of a primary high-grade glioma
• Brain MRI with contrast demonstrates an enhancing mass within 60 days prior to registration. Patient must be deemed a candidate for LITT from MRI by Neurosurgery in order to be eligible.
• History and physical including neurological exam within 30 days prior to registration
• Karnofsky performance status ≥50% within 30 days prior to registration
• Age ≥ 18 years old
• Patients must have signed an approved informed consent
• Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.
• Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.

You may not qualify if…

• Patients that are not surgical candidates for stereotactic biopsy or laser ablation
• Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following:
• History or presence of serious uncontrolled ventricular or significant arrhythmias.
• Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism
• Infratentorial tumor or evidence of leptomeningeal spread
• Inability to undergo a MRI
• Pregnant or breast-feeding women

Where it is running

• Maryland Proton Treatment Center — Baltimore, Maryland, United States (enrolling)
• University of Maryland Greenebaum Cancer Center — Baltimore, Maryland, United States (enrolling)
• UCH Kaufman Cancer Center — Bel Air, Maryland, United States (enrolling)
• Central Maryland Radiation Oncology — Columbia, Maryland, United States (enrolling)
• Baltimore Washington Medical Center — Glen Burnie, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.