Investigating the Utility of Demyelination Tracer [18F]3F4AP in Controls and Multiple Sclerosis Subjects

Recruiting now · Phase 1

Conditions studied: Multiple Sclerosis

In brief

Our overall objective is to obtain an initial assessment of the potential value of using \[18F\]3F4AP for imaging demyelinating diseases such as multiple sclerosis: * Aim 1) Assess the safety of \[18F\]3F4AP in healthy volunteers and subjects with multiple sclerosis (MS). Hypothesis 1: Administration of \[18F\]3F4AP will result in no changes in vitals or other adverse events. * Aim 2) Assess the pharmacokinetics of a bolus infusion of \[18F\]3F4AP in humans including healthy volunteers and MS patients. Hypothesis 2: the pharmacokinetics of \[18F\]3F4AP at the whole brain level will be similar in controls and MS subjects. The kinetics in demyelinated lesions will be slower than in healthy control areas. * Aim 3) Assess the reproducibility of \[18F\]3F4AP in humans. Hypothesis 3: the test/retest variability of \[18F\]3F4AP within the same subject will be lower than 10%. * Aim 4) Correlate MR brain images with \[18F\]3F4AP PET brain images. Hypothesis 4A: all the lesions seen on the MRI will show increased signal (VT or SUV) on the PET images. Hypothesis 4B: some of the lesions on the MRI will show increased signal (VT or SUV) on the PET but not all. * Aim 5) Correlate \[18F\]3F4AP PET signal with neuropsychological testing in people with MS. Hypothesis 5: increased PET signal (VT or SUV) will correlate with impaired Single Digit Modality Test (SDMT) scores. * Aim 6) Correlate \[18F\]3F4AP PET signal with EDSS score in people with MS. Hypothesis 6: increased PET signal (VT or SUV) will correlate with higher EDSS scores.

Key facts

Study ID: NCT04699747
Run by: Massachusetts General Hospital
People needed: 60
Starts: 2021-03-25
Expected to finish: 2026-11-30
Last updated by the study team: 2025-02-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Subjects must be ≥18 and <65 years of age;
Able to understand and provide informed consent prior to study procedures

You may not qualify if…

Subjects with known structural brain disease (e.g. brain tumor or stroke);
Any contraindication to MRI and/or PET, including:
Subjects with life vest;
Subjects with implanted heart device (e.g. ICD, Pacemaker);
Subjects with metallic fragment or foreign body;
Subjects with other form of devices or prosthesis that are not MRI compatible, such as insulin pump, joint replacement, hearing aid, cochlear implant, permanent contraceptive devices, etc.;
Subjects with severe claustrophobia
Relative or absolute contraindication to Dotarem contrast:
history of renal disease including acute or chronic severe renal insufficiency (glomerular filtration rate <60 mL/min/1.73m2);
history of diabetes mellitus, systemic lupus, multiple myeloma, nephrogenic systemic fibrosis, and other co-morbidities;
History of hypersensitive reactions to Dotarem and/or gadolinium contrast agent;
Radiation exposure exceeds current Radiology Department guidelines (i.e., 50 mSv in the prior 12 months);
Female subjects only: Positive serum pregnancy test, or lactating, or possibility of pregnancy cannot be ruled out prior to dosing;
Inability to provide written informed consent;
Any clinically significant acute or unstable physical or psychiatric condition, judged by the investigators based on medical history or screening physical examination, to be incompatible with the study;
Any physical or psychiatric condition judged by the investigators to be incompatible with the study, based on medical history or screening physical examination;
Abnormal results on blood tests judged by the investigators to be incompatible with the study.

Where it is running

Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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