Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans

Running, not enrolling · Not applicable · Has a placebo group

Conditions studied: Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content

In brief

Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality. Nicotinamide adenine dinucleotide (NAD) is a critical co-factor needed for many cellular processes. The natural levels of NAD decline aging and this has been linked to physical performance decline in animals. Human trials have demonstrated that nicotinamide riboside (NR), a form of vitamin B3, is safe and effectively increases NAD+ levels. In animal studies, NR improves treadmill performance and muscle quality. Here the investigators propose a double-blind randomized control trial to assess the benefits of NR supplementation on human muscle function and physiology. The investigators anticipate the research findings will support the use of this nutritional supplement to improve the health of Veterans during aging.

Key facts

Study ID

NCT04691986

Run by

VA Office of Research and Development

People needed

74

Starts

2023-09-01

Expected to finish

2027-06-30

Last updated by the study team

2026-07-21

Who can join

Age: 65 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Ages 65-85
• Male or female
• Any race
• Ability to use an exercise bike
• Medically cleared for muscle biopsy

You may not qualify if…

• Severe Co-morbidity
• examples include, but not limited to:
• congestive heart failure class equal to or above III
• chronic obstructive pulmonary disorder (COPD) gold stage IV
• chronic kidney disease equal to or above stage
• A VA-SLUMS cognitive screen score of less than or equal to 20
• Body mass index greater than or equal to 40

Where it is running

• Kansas City VA Medical Center, Kansas City, MO — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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