Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients

Status unconfirmed

Conditions studied: COVID-19, Endothelial Function

In brief

The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alterations with 28-day mortality in ICU COVID-19 patients.

Key facts

Study ID

NCT04689477

Run by

Corporacion Parc Tauli

People needed

612

Starts

2020-05-25

Expected to finish

2022-10-01

Last updated by the study team

2022-08-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Recent diagnosis of SARS-CoV2 infection
• Arterial hypoxemia and bilateral alveolar infiltrates, not explained by cardiac dysfunction or fluid overload.

You may not qualify if…

• Severe peripheral vasculopathy
• Raynaud's syndrome
• Skin lesions or trauma in upper limbs interfering the placement of NIRS probe and/or the occlusion tourniquet
• Deep venous thrombosis in the upper limbs

Where it is running

• University of Texas Southwestern Medical Center — Dallas, Texas, United States (enrolling)
• Hospital de Clinicas da UNICAMP — Campinas, São Paulo, Brazil (enrolling)
• Hospital Das Clínicas University of Sao Paulo Medical School — São Paulo, Brazil (enrolling)
• Hospital General de México — México, Mexico (enrolling)
• Institut d'Investigació i Innovació Parc Taulí — Sabadell, Barcelona, Spain (enrolling)
• Hospital Clínic i Provincial de Barcelona — Barcelona, Spain (enrolling)
• Hospital Parc Salut Mar — Barcelona, Spain (enrolling)
• Hospital Vall d'Hebron — Barcelona, Spain (enrolling)

Full record on ClinicalTrials.gov

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