CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Recruiting now

Conditions studied: Mitral Regurgitation, Mitral Valve Disease, Mitral Annular Calcification

In brief

This multinational, investigator-initiated registry aims to investigate clinical outcomes of patients undergoing transcatheter mitral valve replacement (TMVR). The registry primarily focuses on patients treated with TMVR in real-world clinical practice. Patients evaluated for TMVR but not undergoing the procedure are no longer systematically included. Historical data may include such patients who subsequently underwent alternative treatments, including transcatheter edge-to-edge repair, mitral valve surgery, or medical/conservative therapy.

Key facts

Study ID

NCT04688190

Run by

Universitätsklinikum Hamburg-Eppendorf

People needed

1000

Starts

2020-11-01

Expected to finish

2030-12-31

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• clinically significant mitral insufficiency
• patient underwent screening for TMVI
• echocardiography data at baseline (and after TMVI, E2E and surgery)
• follow-up of at least 30 days

You may not qualify if…

• age under 18 years

Where it is running

• Tucson Medical Center — Tucson, Arizona, United States (enrolling)
• Cedars-Sinai Medical Center, Los Angeles — Los Angeles, California, United States (enrolling)
• Tampa General Hospital — Tampa, Florida, United States (enrolling)
• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
• Minneapolis Heart Institute at Abbott Northwestern Hospital — Minneapolis, Minnesota, United States (enrolling)
• Morristown Medical Center — Morristown, New Jersey, United States (enrolling)
• Montefiore Medical Center — New York, New York, United States (enrolling)
• Oklahoma Heart Hospital — Oklahoma City, Oklahoma, United States (enrolling)
• Houston Methodist Hospital — Houston, Texas, United States (enrolling)
• St Vincent's Hospital — Sydney, Australia (enrolling)
• Medical University of Vienna — Vienna, Austria (enrolling)
• Québec Heart and Lung Institute (Laval University) — Québec, Quebec, Canada (enrolling)
• Toronto Heart Center — Toronto, Canada (enrolling)
• St. Paul's Hospital — Vancouver, Canada (enrolling)
• Rigshospitalet — Copenhagen, Denmark (enrolling)
• CHU Bordeaux — Bourdeaux, France (enrolling)
• Lille University Hospital — Lille, France (enrolling)
• Civils Hospices of Lyon — Lyon, France (enrolling)
• Clinique Pasteur — Toulouse, France (enrolling)
• HDZ Bad Oeynhausen — Bad Oeynhausen, Germany (enrolling)
• German Heart Center Berlin — Berlin, Germany (enrolling)
• Heart Center Bonn — Bonn, Germany (enrolling)
• University Hospital of Cologne — Cologne, Germany (enrolling)
• Goethe-Universität - University Hospital Frankfurt — Frankfurt, Germany (enrolling)
• University Heart and Vascular Center Hamburg — Hamburg, Germany (enrolling)

Full record on ClinicalTrials.gov

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