Compressed Intermittent Theta Burst Stimulation
Running, not enrolling · Not applicable
Conditions studied: Treatment Resistant Depression
In brief
In this proposal the investigators will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a previously published study demonstrating clinical efficacy of intermittent theta-burst stimulation (iTBS) on left dorsolateral prefrontal cortex (L-dlPFC) in a treatment refractory population.
Key facts
- Study ID
- NCT04684706
- Run by
- University of Pennsylvania
- People needed
- 40
- Starts
- 2020-02-20
- Expected to finish
- 2027-01-20
- Last updated by the study team
- 2026-01-16
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Gender, inclusive
- 18 - 70 years of age
- Meets Diagnostic and Statistical Manual of Mental Disorders criteria for primary diagnosis of MDD
- Patients must be fluent in English
- Participants must have the ability to provide consent
- Montgomery Asberg Depression Rating Scale score ≥20
- Failed 2+ prior treatments (treatment-refractory)
- May be on current anti-depressant medication at the discretion of PI, if not exceeding doses that would make TMS an increased risk
You may not qualify if…
- Pregnancy (Female participants)
- MRI contraindication
- Medical condition that interferes with the collection or interpretation of MRI data
- Implanted devices such as: aneurysm clip or cardiac pacemaker
- Diagnosis of stroke, epilepsy, or other neurological disorders interfering with treatment at PI discretion
- Any factor the investigator believe may affect participant safety or compliance (ex: ≥100 miles from clinic)
- Current alcohol or substance use disorder in last 3 months
Where it is running
- Department of Interventional Psychiatry, University of California San Diego — La Jolla, California, United States
- Center for Neuromodulation in Depression and Stress — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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