A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

Recruiting now

Conditions studied: Familial Adenomatous Polyposis

In brief

The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.

Key facts

Study ID

NCT04678011

Run by

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

People needed

1000

Starts

2021-11-24

Expected to finish

2026-11-01

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (>100 colorectal adenomas in combination with a positive family history of FAP)
• Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
• Age 18 years or older

You may not qualify if…

• Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
• Cancer at baseline endoscopy
• Need for surgery

Where it is running

• MD Anderson — Houston, Texas, United States (enrolling)
• Academic Medical Centre — Amsterdam, North Holland, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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