Coupling Negative Pressure Wound Therapy With Instillation

Stopped early · Not applicable

Conditions studied: Wound, Ulcer, Burns

In brief

The objective of this study is to compare standard negative pressure wound therapy with negative pressure wound therapy coupled with instillation for optimal skin graft take. Either the V.A.C ULTA NPWT or V.A.C. VeraFlo Therapy systems with normal saline will be applied intra-operatively to split-thickness skin grafts of upper and lower extremity wounds and kept in place for a duration of four days. Following completion of four days, the skin graft with be assessed for percentage of take/adherence and will be covered with simple gauze dressings as needed.

Key facts

Study ID

NCT04677166

Run by

Loma Linda University

People needed

6

Starts

2021-01-19

Expected to finish

2024-10-21

Last updated by the study team

2025-06-13

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who have been offered split-thickness skin graft for treatment of an extremity wound.

You may not qualify if…

• Abnormal healing (diagnosed with connective tissue disorder)
• Uncontrolled diabetes mellitus (HgbA1c >9)

Where it is running

• Loma Linda University — Loma Linda, California, United States

Full record on ClinicalTrials.gov

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