Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections

Completed · Phase 2

Conditions studied: Drug Use, Opioid-use Disorder

In brief

This study will assess the efficacy of an integrated outpatient treatment model for persons with opioid use disorder and injection related infections. The investigators hypothesize that outpatient antibiotic treatment coupled with comprehensive treatment for opioid use disorder will demonstrate a safe and effective way to manage patients. Results could improve the current protocols for the treatment of individuals with opioid use disorder and severe infections.

Key facts

Study ID: NCT04677114
Run by: Laura Fanucchi
People needed: 71
Starts: 2021-03-16
Expected to finish: 2025-03-06
Last updated by the study team: 2026-04-28

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

have opioid use disorder
have a severe injection related infection requiring antibiotics
willing to accept buprenorphine treatment
anticipated to be discharged home
require IV antibiotic therapy

You may not qualify if…

stroke or cerebral mycotic aneurysms preventing aortic or mitral valve surgery
fungal valve IE
requiring in-patient rehabilitation
current pregnancy
hypersensitivity or allergy to buprenorphine
class III or IV heart failure
end-stage liver or renal disease
any condition that may prevent the volunteer from safely participating in the study
self-report of desire to inject into the PICC line
pending legal action that could interfere with study participation
unsafe or unstable environment precluding safe administration of IV antibiotics
living more than a 60 minute drive outside of Lexington, KY

Where it is running

University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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