iCorMicA - Stratified Medicine in Angina
Recruiting now · Not applicable
Conditions studied: Microvascular Angina, Angina, Stable, Ischemia With No Obstructive Coronary Arteries (INOCA), Coronary Microvascular Dysfunction (CMD), Ischaemic Heart Disease, Non-Obstructive Coronary Atherosclerosis, Coronary Artery Disease, Vasospastic Angina, Coronary; Ischemic, Angina Attacks
In brief
The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.
Key facts
- Study ID
- NCT04674449
- Run by
- NHS Greater Glasgow and Clyde
- People needed
- 1500
- Starts
- 2020-12-30
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-04-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years.
- A clinical plan for invasive coronary angiography.
- Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
- Able to comply with study procedures.
- Able to provide informed consent.
You may not qualify if…
- A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
- History of coronary artery bypass surgery.
- Presence of obstructive disease evident in a main coronary artery (diameter >2.5 mm), i.e. a coronary stenosis >50% and/or a fractional flow reserve (FFR) ≤0.80*.
- Logistical reason*. *These patients will enter a follow-up registry.
Where it is running
- New Cross Hospital — Wolverhampton, United Kingdom (enrolling)
- The Newcastle upon Tyne Hospitals NHS Foundation Trust — Newcastle upon Tyne, United Kingdom (enrolling)
- Royal Gwent Hospital — Newport, United Kingdom (enrolling)
- Nottingham University Hospitals NHS TRUST — Nottingham, United Kingdom (enrolling)
- Queen Alexandra Hospital — Portsmouth, United Kingdom (enrolling)
- Northern General Hospital — Sheffield, United Kingdom (enrolling)
- University Hospital Southampton — Southampton, United Kingdom (enrolling)
- South Tyneside and Sunderland NHS Foundation Trust — Sunderland, United Kingdom (enrolling)
- Morriston Hospital — Swansea, United Kingdom (enrolling)
- Pinderfields General Hospital — Wakefield, United Kingdom (enrolling)
- Radboud University Medical Centre — Nijmegen, Netherlands (enrolling)
- 5th Military Hospital — Krakow, Poland (enrolling)
- Golden Jubilee National Hospital — Clydebank, Scotland, United Kingdom (enrolling)
- William Harvey Hospital — Ashford, United Kingdom (enrolling)
- Bedford Hospital NHS Trust — Bedford, United Kingdom (enrolling)
- Royal Victoria Hospital — Belfast, United Kingdom (enrolling)
- Birmingham Heartlands Hospital — Birmingham, United Kingdom (enrolling)
- Royal Blackburn Teaching Hospital — Blackburn, United Kingdom (enrolling)
- Victoria Hospital — Blackpool, United Kingdom (enrolling)
- Glan Clwyd Hospital — Bodelwyddan, United Kingdom (enrolling)
- University Hospital of Wales — Cardiff, United Kingdom (enrolling)
- St Peter's Hospital NHS Foundation Trust — Chertsey, United Kingdom (enrolling)
- University Hospitals Coventry & Warwickshire NHS Trust — Coventry, United Kingdom (enrolling)
- University Hospital Hairmyres — East Kilbride, United Kingdom (enrolling)
- Raigmore Hospital — Inverness, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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