Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration
Completed · Phase 1
Conditions studied: Infection, Hand Injury Wrist, Hand Injuries, Hand Injuries and Disorders, Hand Arthritis
In brief
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than the current standard dose which is given intravenously (IV).
Key facts
- Study ID
- NCT04673877
- Run by
- Mayo Clinic
- People needed
- 20
- Starts
- 2021-08-26
- Expected to finish
- 2022-08-17
- Last updated by the study team
- 2022-10-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients undergoing upper extremity reconstruction by a single surgeon.
- Surgical cases will include:
- Trapeziectomy/suspensionplasty.
- PIPJ/MPJ arthroplasty.
- Proximal row carpectomy.
- Distal ulnar resection.
- Distal radius fracture fixation.
You may not qualify if…
- Inability to adequately cannulate a superficial vein in the upper extremity within 5 minutes of tourniquet inflation.
- Evidence of subcutaneous extravasation in Bier block group.
- History of renal dysfunction.
- Vancomycin allergy.
- ASA>/= 3.
- History of lung cancer.
- Known HIV infection.
- History of organ transplantation.
Where it is running
- Mayo Clinic in Arizona — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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