A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

Completed · Phase 1

Conditions studied: Advanced Solid Tumors, Solid Tumors, Ovarian Cancer, Breast Cancer, Prostate Cancer, NSCLC, Pancreatic Cancer, Colorectal Cancer

In brief

This will be a Phase 1, open label, 2-sequence, crossover study to establish the BE of the current commercial formulation (Generation 3.1 talazoparib capsules) to the proposed talazoparib liquid-filled soft gelatin capsule (soft gel capsule) formulation after multiple dosing under fasting conditions in participants with advanced solid tumors. In addition, the effect of food on the PK of the proposed talazoparib soft gel capsule formulation will be evaluated in fixed sequence after the 2 BE assessment periods.

Key facts

Study ID

NCT04672460

Run by

Pfizer

People needed

73

Starts

2020-12-21

Expected to finish

2022-07-22

Last updated by the study team

2024-09-25

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histological diagnosis of recurrent, locally advanced or metastatic solid tumor that is not amenable for treatment with curative intent.
• Solid tumors with known or likely pathogenic germline or somatic tumor gene defect (eg, one or more BRCA1 or BRCA2 gene defect except for ovarian cancer) that would benefit from PARPi therapy per current approvals for the tumor indication or supported by strong scientific evidence.
• Received at least 1 prior SOC regimen, if it exists, as appropriate for the respective tumor type unless deemed unsuitable or declined these therapies; ovarian cancer participants must have at least 1 prior cytotoxic chemotherapy regimen, including at least 1 course of platinum-based therapy. Participants must not have had disease progression within 6 months of initiation of platinum containing regimen.
• ECOG performance score of 0-1.
• Adequate bone marrow function:
• ANC ≥1500 cells/mm3
• Platelets ≥100,000 cells/mm3
• Hemoglobin ≥10.0 g/dL
• Adequate organ functions:
• CLCR ≥60 mL/min and no documented CLCR <60 mL/min and no change in CLCR >25% in the past 4 weeks
• AST and ALT ≤2.5 × ULN; if liver function abnormalities are due to hepatic metastasis, then AST and ALT ≤5 × ULN;
• Total bilirubin ≤1.5 × ULN (≤3 × ULN for Gilbert's syndrome);

You may not qualify if…

• For ovarian participants: Non-epithelial tumors or ovarian tumors with low malignant potential (ie, borderline tumors) or mucinous tumors.
• Toxicities from previous anti-cancer therapies must be resolved to NCI CTCAE <Grade 2, except for alopecia, sensory neuropathies ≤Grade 2, or other Grade ≤2 AEs not constituting a safety risk, based on investigator's judgment, are acceptable.
• Diagnosed with MDS or AML.
• Active infection requiring systemic therapy within 2 weeks of enrollment.
• Any condition in which active bleeding or pathological conditions may carry a high risk of bleeding (eg, known bleeding disorder, coagulopathy or tumor involvement with major vessels).
• Known or suspected brain metastasis or active leptomeningeal disease undergoing or requiring treatment. Asymptomatic brain metastases currently not undergoing treatment are allowed.
• Known history of testing positive for HIV, AIDS, positive HBV surface antigen, positive HCV RNA, or positive COVID-19 viral test. Asymptomatic patients with no active infection detected but positive antibody tests, indicating past infection, are allowed.
• Current or anticipated use of P-gp inhibitors, BCRP inhibitors, and P-gp inducers within 2 weeks or 5 half-lives prior to randomization (whichever is longer) .

Where it is running

• California Cancer Associates for Research and Excellence, Inc (cCARE) — Encinitas, California, United States
• Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• California Cancer Associates for Research and Excellence, Inc (cCARE) — San Marcos, California, United States
• Smilow Cancer Hospital at Yale New Haven — New Haven, Connecticut, United States
• Yale-New Haven Hospital — New Haven, Connecticut, United States
• Smilow Cancer Hospital Phase 1 Unit — New Haven, Connecticut, United States
• Florida Cancer Specialists — Lake Mary, Florida, United States
• Alliance for Multispecialty Research, LLC — Kansas City, Missouri, United States
• NYU Langone Hospital - Long Island Oncology — Mineola, New York, United States
• NYU Langone Hospital - Long Island — Mineola, New York, United States
• Laura & Isaac Perlmutter Cancer Center at NYU Langone Health — New York, New York, United States
• NYU Investigational Pharmacy — New York, New York, United States
• NYU Langone Medical Center (Tisch Hospital) — New York, New York, United States
• Montefiore Medical Center — The Bronx, New York, United States
• University of Cincinnati Medical Center — Cincinnati, Ohio, United States
• University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
• West Chester Hospital — West Chester, Ohio, United States
• UPCI Investigational Drug Service — Pittsburgh, Pennsylvania, United States
• UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
• Upmc Shadyside — Pittsburgh, Pennsylvania, United States
• Mary Crowley Cancer Research - Medical City Hospital — Dallas, Texas, United States
• NEXT Oncology — San Antonio, Texas, United States
• Liverpool Cancer Therapy Centre — Liverpool, New South Wales, Australia
• Liverpool Hospital — Liverpool, New South Wales, Australia

Full record on ClinicalTrials.gov

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