Mechanistic Interventions and Neuroscience of Dissociation

Recruiting now · Not applicable

Conditions studied: Dissociation

In brief

The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people. The intervention will be tested in dissociative traumatized people at two sites: Emory University and University of Pittsburgh. The researchers are interested in whether neural networks associated with attentional control and interoceptive awareness can be enhanced in this population. The researchers propose to evaluate whether different body-focused and non-body focused interventions can change these mechanisms.

Key facts

Study ID

NCT04670640

Run by

Emory University

People needed

350

Starts

2021-09-18

Expected to finish

2027-03-01

Last updated by the study team

2026-04-20

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• experience of at least one Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Criterion A trauma (assessed using the Life Events Checklist)
• a score of 7 or higher on the Multiscale Dissociation Inventory (MDI) depersonalization subscale
• willingness to participate in the study

You may not qualify if…

• actively psychotic and cognitively compromised individuals (assessed using the Moderate-severe cognitive impairment screening tool (MoCA) will be excluded
• moderate or more severe substance dependence (assessed with the MINI)
• persons with imminent risk of physical violence to self or others

Where it is running

• Grady Hospital — Atlanta, Georgia, United States (enrolling)
• Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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