Longitudinal Investigation of Brain Blood Flow Changes in Neurosurgical Patients
Recruiting now
Conditions studied: Brain Blood Flow Impairment
In brief
Primary study objective: • Longitudinal observation of brain blood flow changes in neurosurgical patients with or without a neurosurgical intervention as compared to a healthy cohort. Secondary study objectives: * Longitudinal observation of hemodynamic patterns versus structural brain tissue changes in neurosurgical patients. * Changes in blood flow patterns and structural brain tissue after neurosurgical interventions as compared to a healthy cohort. * Determining hemodynamic imaging patterns that can be tested as novel imaging markers.
Key facts
- Study ID
- NCT04668261
- Run by
- University of Zurich
- People needed
- 400
- Starts
- 2021-01-01
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2020-12-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients:
- Male and Female subjects >18 years of age
- Written informed consent after participants' information. Foreign speaking patients should be accompanied by a person with sufficient German language proficiency to act as a translator
- Neurosurgical diseases with the potential to alter blood flow to the brain:
- Cerebrovascular disease
- Brain tumors
- Normal Pressure Hydrocephalus
- Healthy subjects:
- Male and Female subjects >18 years of age
- Written Informed Consent by the participant after information about the project. Foreign speaking healthy subjects should be accompanied by a person with sufficient German language proficiency to act as a translator
You may not qualify if…
- Patients:
- Unwilling or unable to co-operate with breathing maneuvers
- Respiratory or cardiac limitations to breathing through a mask
- Medical contra-indications to limited hypercapnia (high CO2 - 50 mmHg) or hypocapnia (low CO2 - 30 mmHg) (i.e., known increased intracerebral pressure, metabolic acidosis or alkalosis)
- Standard contraindications for MRI scanning
- Verbal confirmed pregnancy
- Known multiple intracranial diseases
- Presence of intracranial hemorrhage within the last 3 months
- Symptomatic increased intracranial pressure
- Healthy subjects:
- Unwilling or unable to co-operate with breathing maneuvers
- Respiratory or cardiac limitations to breathing through a mask
- Medical contra-indications to limited hypercapnia (high CO2 - 50 mmHg) or hypocapnia (low CO2 - 30 mmHg) (i.e., known increased intracerebral pressure, metabolic acidosis or alkalosis)
- Standard contraindications for MRI scanning
- Verbal confirmed pregnancy
- Anamnesticly a history of neurological disease or current neurological deficits.
Where it is running
- University Hospital Zurich — Zurich, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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