A Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants With Recurrent/Metastatic PD-L1 Positive Squamous Cell Carcinoma of the Head and Neck
Completed · Phase 2 · Has a placebo group
Conditions studied: Squamous Cell Carcinoma of Head and Neck
In brief
The primary objective of this study is to evaluate the efficacy of atezolizumab plus tiragolumab and atezolizumab plus placebo as first-line (1L) treatment in recurrent/metastatic PD-L1-positive squamous cell carcinoma of the head and neck (SCCHN) on the basis of confirmed objective response rate. In addition, safety, pharmacokinetics, immunogenicity of atezolizumab and tiragolumab will be evaluated.
Key facts
- Study ID
- NCT04665843
- Run by
- Hoffmann-La Roche
- People needed
- 123
- Starts
- 2021-03-02
- Expected to finish
- 2025-08-27
- Last updated by the study team
- 2026-05-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Moores Cancer Center at UC San Diego Health — La Jolla, California, United States
- UCLA — Los Angeles, California, United States
- SCRI Florida Cancer Specialists PAN — Tallahassee, Florida, United States
- Johns Hopkins Hospital — Baltimore, Maryland, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Tennessee Oncology - Nashville — Nashville, Tennessee, United States
- MD Anderson Cancer Center — Houston, Texas, United States
- Masarykuv onkologicky ustav — Brno, Czechia
- Fakultni nemocnice Hradec Kralove — Hradec Králové, Czechia
- Fakultni nemocnice v Motole — Prague, Czechia
- CHU Bordeaux — Bordeaux, France
- Centre Francois Baclesse — Caen, France
- Centre Leon Berard — Lyon, France
- Institut régional du Cancer Montpellier — Montpellier, France
- Institut Curie — Paris, France
- Institut de Cancérologie de Lorraine — Vandœuvre-lès-Nancy, France
- Anticancer Hospital Ag Savas — Athens, Greece
- Attiko Hospital University of Athens — Athens, Greece
- Periph. University General Hospital of Heraklion Crete — Heraklion, Greece
- Euromedical General Clinic of Thessaloniki — Thessaloniki, Greece
- Gy?r-Moson-Sopron Vármegyei Petz Aladár Egyetemi Oktató Kórház — Gy?r, Hungary
- Bacs-Kiskun Megyei Korhaz, SZTE AOK Oktato Korhaza, Onkoradiologiai Kozpont — Kecskemét, Hungary
- Pécsi Tudományegyetem — Pécs, Hungary
- Asst Degli Spedali Civili Di Brescia — Brescia, Lombardy, Italy
- Fondazione IRCCS Istituto Nazionale dei Tumori — Milan, Lombardy, Italy
Full record on ClinicalTrials.gov
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