Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding

Recruiting now

Conditions studied: GastroIntestinal Bleeding

In brief

Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointestinal bleeding.

Key facts

Study ID

NCT04662918

Run by

Xingshun Qi

People needed

3000

Starts

2022-01-01

Expected to finish

2025-12-01

Last updated by the study team

2025-10-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with liver cirrhosis;
• Patients with acute gastrointestinal bleeding presenting with hematemesis, melena, and/or hematochezia;
• Adults (age≥18 years old).

You may not qualify if…

• Components of Child-Pugh, MELD, and CAGIB scores are not available;
• In-hospital outcomes are not evaluable.

Where it is running

• Bezmialem Vakif University — Istanbul, Istanbul, Turkey (Türkiye) (enrolling)
• São Paulo State University (UNESP), Botucatu Medical School — São Paulo, São Paulo, Brazil (enrolling)
• Beijing Youan Hospital, Capital Medical University — Beijing, Beijing Municipality, China (enrolling)
• Shandong Provincial Hospital — Jinan, Shandong, China (enrolling)
• Charité University Medical Center — Berlin, State of Berlin, Germany (enrolling)
• Azienda di Rilievo Nazionale ad Alta Specializzazione Civico-Di Cristina-Benfratelli — Palermo, Palermo, Italy (enrolling)
• National Autonomous University of Mexico — Mexico City, Mexico City, Mexico (enrolling)
• First Affiliated Hospital of Fujian Medical University — Fuzhou, Fujian, China (enrolling)
• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
• First Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China (enrolling)
• The Six People's Hospital of Dalian — Dalian, Liaoning, China (enrolling)
• Air Force Hospital of Northern Theater Command — Shenyang, Liaoning, China (enrolling)
• General Hospital of Northern Theater Command — Shenyang, Liaoning, China (enrolling)
• The First Hospital of China Medical University — Shenyang, Liaoning, China (enrolling)
• The Six People's Hospital of Shenyang — Shenyang, Liaoning, China (enrolling)
• Tangdu Hospital, Fourth Military Medical University, — Xi'an, Shaanxi, China (enrolling)
• The First Affiliated Hospital of Xi'an Jiao Tong University — Xi'an, Shaanxi, China (enrolling)
• The Second Affiliated Hospital of Xi'an Jiao Tong University — Xi'an, Shaanxi, China (enrolling)
• Xi'an Central Hospital — Xi'an, Shaanxi, China (enrolling)
• The Seventh Medical Center of Chinese PLA General Hospital — Beijing, Beijing Municipality, China
• Ernakulam Medical Center — Kochi, Kochi, India
• Cathay General Hospital, Fu-Jen Catholic University School of Medicine — Taibei, Taiwan, China
• The Wright Center for Graduate Medical Education, 501 S. Washington Avenue — Scranton, Pennsylvania, United States

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