Efficacy and Safety of LX9211 in Participants With Postherpetic Neuralgia

Completed · Phase 2 · Has a placebo group

Conditions studied: Postherpetic Neuralgia

In brief

Evaluation of the efficacy of LX9211 compared to placebo in reducing pain related to postherpetic neuralgia over an 11 week assessment period.

Key facts

Study ID

NCT04662281

Run by

Lexicon Pharmaceuticals

People needed

79

Starts

2020-12-10

Expected to finish

2022-12-28

Last updated by the study team

2026-02-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant has given written informed consent to participate in the study in accordance with local regulations
• Adult male and female participants ≥18 years of age at the time of screening
• Postherpetic neuralgia (PHN) pain that is present for ≥3 months after healing of herpes zoster skin rash affecting a single dermatome (Participants with more than 1 involved dermatome may also be included, provided the affected dermatomes are contiguous)
• Moderate to severe pain as confirmed by average pain score using scores recorded in the pain diary in the 14 days prior to randomization

You may not qualify if…

• Presence of other painful conditions that may confound assessment or self-evaluation of PHN
• History of major depressive episode, active, significant psychiatric disorders
• History of clinically significant drug or alcohol use disorder
• PHN affecting the face
• Use of opioid medications for management of PHN within the 2 months prior to Screening Visit
• Use of Non-steroidal anti-inflammatory drugs (NSAIDs) for the specific treatment of PHN pain

Where it is running

• Lexicon Investigational Site — Scottsdale, Arizona, United States
• Lexicon Investigational Site — Tucson, Arizona, United States
• Lexicon Investigational Site — Greenbrae, California, United States
• Lexicon Investigational Site — Brandon, Florida, United States
• Lexicon Investigational Site (113) — Miami, Florida, United States
• Lexicon Investigational Site — Miami, Florida, United States
• Lexicon Investigational Site — Miami, Florida, United States
• Lexicon Investigational Site — Ormond Beach, Florida, United States
• Lexicon Investigational Site — Winter Park, Florida, United States
• Lexicon Investigational Site (147) — Marietta, Georgia, United States
• Lexicon Investigational Site — Flossmoor, Illinois, United States
• Lexicon Investigational Site — Wauconda, Illinois, United States
• Lexicon Investigational Site — Boston, Massachusetts, United States
• Lexicon Investigational Site — Canton, Michigan, United States
• Lexicon Investigational Site — Hazelwood, Missouri, United States
• Lexicon Investigational Site — Albuquerque, New Mexico, United States
• Lexicon Investigational Site (148) — Cary, North Carolina, United States
• Lexicon Investigational Site — Jenkintown, Pennsylvania, United States
• Lexicon Investigational Site — Baytown, Texas, United States
• Lexicon Investigational Site — Victoria, Texas, United States
• Lexicon Investigational Site — Salt Lake City, Utah, United States
• Lexicon Investigational Site — Kenosha, Wisconsin, United States
• Lexicon Investigational Site (138) — Choceň, Czechia
• Lexicon Investigational Site (140) — Pardubice, Czechia
• Lexicon Investigational Site (136) — Prague, Czechia

Full record on ClinicalTrials.gov

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