Study of Late-foetal Human Organ Development

Recruiting now

Conditions studied: Congenital Disorders

In brief

Knowledge about abnormal organ development is important to understand pathology and to develop novel treatment approaches for individuals with congenital and acquired disease. Most of our current understanding is based on examination of tissues from the embryo and early fetus, collected from women undergoing termination of pregnancy in the first trimester (third) of pregnancy. There is very little known about normal and abnormal organ development from a developmental perspective during the crucial last two-thirds of pregnancy when much remodelling of fetal tissues occurs. We aim to collect tissue from a variety of developing fetal organs in the last two-thirds of pregnancy from women who decide to undergo a termination of pregnancy and who wish to undergo a clinical fetal postmortem (PM) examination.

Key facts

Study ID

NCT04661059

Run by

University College London Hospitals

People needed

2000

Starts

2022-02-03

Expected to finish

2040-12-31

Last updated by the study team

2023-12-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ≥18 years old pregnant women who attend the Fetal Medicine Unit for concerns about a fetal abnormality where they decide to proceed to termination of pregnancy

You may not qualify if…

• Screening labs positive for maternal HIV, Hepatitis B and Hepatitis C, Chlamydia and Herpes.
• Subject unable to make an informed decision about termination of pregnancy.

Where it is running

• University College Hospitals NHS Foundation Trust — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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