A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight for the Maintenance of Weight Loss
Completed · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight
In brief
This was a study of tirzepatide in participants with obesity or overweight. The main purpose was to learn more about how tirzepatide maintained body weight loss. The study had two phases: a lead-in phase in which all participants took tirzepatide and a treatment phase in which participants either continued tirzepatide or switched to placebo. The study lasted about 2 years (25 visits).
Key facts
- Study ID
- NCT04660643
- Run by
- Eli Lilly and Company
- People needed
- 783
- Starts
- 2021-03-29
- Expected to finish
- 2023-05-18
- Last updated by the study team
- 2024-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Body Mass Index (BMI) ≥30 kilograms per square meter (kg/m²), or ≥27 kg/m² and previous diagnosis with at least one of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease
- History of at least one unsuccessful dietary effort to lose body weight
You may not qualify if…
- Diabetes mellitus
- Change in body weight greater than 5 kg within 3 months prior to starting study
- Obesity induced by other endocrinologic disorders or monogenetic or syndromic forms of obesity
- History of pancreatitis
- Family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- History of significant active or unstable major depressive disorder (MDD) or other severe psychiatric disorder within the last 2 years
- Any lifetime history of a suicide attempt
Where it is running
- Scripps Memorial Hospital La Jolla — La Jolla, California, United States
- National Research Institute - Wilshire — Los Angeles, California, United States
- National Research Institute — Panorama City, California, United States
- Artemis Institute for Clinical Research — San Diego, California, United States
- University Clinical Investigators, Inc. — Tustin, California, United States
- New West Physicians Clinical Research — Golden, Colorado, United States
- Optumcare Colorado Springs - Monument — Monument, Colorado, United States
- Care Partners Clinical Research — Jacksonville, Florida, United States
- South Florida Clinical Research Institute — Margate, Florida, United States
- Renstar Medical Research — Ocala, Florida, United States
- ForCare Clinical Research — Tampa, Florida, United States
- Endocrine Research Solutions, Inc. — Roswell, Georgia, United States
- SKY Clinical Research Network Group-Blake — Union City, Georgia, United States
- East-West Medical Research Institute — Honolulu, Hawaii, United States
- Rocky Mountain Clinical Research — Idaho Falls, Idaho, United States
- Healthcare Research Network - Chicago — Flossmoor, Illinois, United States
- Clinical Investigation Specialists — Gurnee, Illinois, United States
- Midwest Institute For Clinical Research — Indianapolis, Indiana, United States
- American Health Network of Indiana, LLC - New Albany — New Albany, Indiana, United States
- Cotton O'Neil Clinic — Topeka, Kansas, United States
- L-MARC Research Center — Louisville, Kentucky, United States
- Centennial Medical Group — Elkridge, Maryland, United States
- MedStar Health Research Institute (MedStar Physician Based Research Network) — Hyattsville, Maryland, United States
- ActivMed Practices and Research — Methuen, Massachusetts, United States
- Cahaba Research — Pelham, Alabama, United States
Full record on ClinicalTrials.gov
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