Rollover Study for Patients With Sickle Cell Disease Who Have Completed a Prior Novartis-Sponsored Crizanlizumab Study

Recruiting now · Phase 4

Conditions studied: Sickle Cell Disease

In brief

This is a multi-center multi-national rollover study to allow continued access to crizanlizumab for patients with sickle cell disease (SCD) who are on crizanlizumab treatment in a Novartis-sponsored study (parent study) and are benefiting from the treatment as judged by the investigator.

Key facts

Study ID

NCT04657822

Run by

Novartis Pharmaceuticals

People needed

130

Starts

2021-06-10

Expected to finish

2031-06-10

Last updated by the study team

2026-06-08

Who can join

Age: 1 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent/assent, according to local guidelines, signed by the adult patients. In the population under 18 years, it will be signed by the patient and/or by the parents or legal guardian prior to enrolling in the rollover study and receiving study medication
• SCD patient currently enrolled in a Novartis-sponsored study receiving crizanlizumab and has fulfilled all the requirements in the parent study. Patient is currently benefiting from the treatment with crizanlizumab as determined by the investigator and has completed the treatment schedule as planned in the parent study
• Patient has demonstrated compliance to the planned visit schedule in the parent study, and in the opinion of the investigator has shown willingness and ability to comply with future visit schedules

You may not qualify if…

• Patient had permanently discontinued from crizanlizumab study treatment in the parent study before the parent study completion
• Ongoing/unresolved treatment-related Grade 3 or higher AEs, and/or any ongoing AE requiring dose interruption. Patients meeting all other eligibility criteria may be enrolled once toxicities have resolved unless those toxicities were grade 4
• Concurrent participation in any other investigational clinical trial other than the parent study or plan to participate in any other investigational clinical trial
• Pregnant or nursing women
• Women of childbearing potential who are unwilling to be on highly effective contraceptives during dosing and until 15 weeks after stopping treatment with crizanlizumab
• SCD patients who do not meet parent study protocol criteria to continue with crizanlizumab

Where it is running

• Novartis Investigative Site — Tripoli, Lebanon (enrolling)
• Novartis Investigative Site — Khoudh, Oman (enrolling)
• Novartis Investigative Site — Valledupar, Cesar Department, Colombia (enrolling)
• Augusta University Georgia — Augusta, Georgia, United States (enrolling)
• Novartis Investigative Site — Barranquilla, Atlántico, Colombia (enrolling)
• Novartis Investigative Site — Beirut, Lebanon (enrolling)
• University Of Alabama — Birmingham, Alabama, United States (enrolling)
• Novartis Investigative Site — Laken, Belgium
• Novartis Investigative Site — Liège, Belgium
• Novartis Investigative Site — Salvador, Estado de Bahia, Brazil
• Novartis Investigative Site — Ribeirão Preto, São Paulo, Brazil
• Novartis Investigative Site — São Paulo, São Paulo, Brazil
• Novartis Investigative Site — Cali, Valle del Cauca Department, Colombia
• Novartis Investigative Site — Montería, Colombia
• Novartis Investigative Site — Créteil, France
• Novartis Investigative Site — Paris, France
• Novartis Investigative Site — Paris, France
• Novartis Investigative Site — Heidelberg, Germany
• Novartis Investigative Site — Padova, PD, Italy
• Novartis Investigative Site — Orbassano, TO, Italy
• Novartis Investigative Site — Barcelona, Spain
• Novartis Investigative Site — Madrid, Spain
• Novartis Investigative Site — Hatay, Antakya, Turkey (Türkiye)
• Novartis Investigative Site — Adana, Saricam, Turkey (Türkiye)
• Novartis Investigative Site — Adana, Yuregir, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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