4D-MRI for Precision Medicine
Recruiting now
Conditions studied: Healthy Volunteers, Liver Cancer, Lung Cancer
In brief
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For radiation therapy to be effective, the precise size, shape, and location of the tumor within the body must be known. A particular difficulty for radiation treatment of lung and liver cancer is that the tumor moves during treatment because the patient is breathing. Therefore, tumor motion must also be incorporated into the treatment plan. This study aims to improve radiation treatment planning through better targeting and dose estimation based on 4D-MRI. Before this new imaging method can be used for radiation treatment planning, it must be tested in living, breathing volunteers.
Key facts
- Study ID
- NCT04657042
- Run by
- University of Virginia
- People needed
- 100
- Starts
- 2020-11-05
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-05-06
Who can join
Age: 18 and older, up to 82. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Any condition for which a MRI procedure is contraindicated including presence of metallic material in the body, such as pacemakers, non- MRI compatible surgical clips, shrapnel, etc.
- Subjects who have difficulty lying flat on their back for extended periods of time
- Patients with any serious/poorly controlled medical or psychological conditions that would complicate protocol compliance
- Too large to adequately fit in the magnet bore or RF coils
- Claustrophobia
- Females who are pregnant or lactating
- Presence of active or chronic infection
Where it is running
- University of Virginia — Charlottesville, Virginia, United States (enrolling)
Full record on ClinicalTrials.gov
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