Study of TL-895 in Subjects With Myelofibrosis or Indolent Systemic Mastocytosis
Status unconfirmed · Phase 2 · Has a placebo group
Conditions studied: Myelofibrosis, Indolent Systemic Mastocytosis
In brief
This study evaluates TL-895, a potent, orally-available and highly selective irreversible tyrosine kinase inhibitor for the treatment of Myelofibrosis (Cohorts 1-3) or Indolent Systemic Mastocytosis (Cohort 5). Participants must be diagnosed with Myelofibrosis and be relapsed/refractory (e.g., having failed prior therapy), intolerant, or ineligible to receive JAKi treatment, or be diagnosed with Indolent Systemic Mastocytosis.
Key facts
- Study ID
- NCT04655118
- Run by
- Telios Pharma, Inc.
- People needed
- 121
- Starts
- 2020-10-22
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2024-05-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Universitaetsklinikum Jena — Jena, Germany (enrolling)
- Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu, Klinika Hematologii, Nowotworów Krwi i Transplantacji Szpiku — Wroclaw, Poland (enrolling)
- Hospital Universitario 12 de Octubre — Madrid, Spain (enrolling)
- Chu De Liège — Liège, Belgium (enrolling)
- Universitaetsklinikum Carl Gustav Carus Dresden — Dresden, Germany (enrolling)
- Mayo Clinic - Rochester — Rochester, Minnesota, United States (enrolling)
- Institut Catala d'Oncologia - L'Hospitalet — Barcelona, Spain (enrolling)
- Hospital Germans Trias i Pujol — Barcelona, Spain (enrolling)
- Hospital Quirónsalud Zaragoza — Zaragoza, Spain (enrolling)
- University of Texas, MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- Klinik fur Innere Medizin IV - Hamatologie/Onkologie, Universitatsklinikum Hall — Halle, Germany (enrolling)
- St Vincent's Hospital Sydney — Sydney, Australia (enrolling)
- Royal Perth Hospital — Perth, Australia (enrolling)
- Military Medical Academy — Sofia, Bulgaria
- University Hospital "St Ivan Rilski" — Sofia, Bulgaria
- Border Medical Oncology — East Albury, Australia
- Instituto de Estudos e Pesquisas Sao Lucas - IEP - Sao Lucas — São Paulo, Brazil
- Debreceni Egyetem Klinikai Kozpont — Debrecen, Hungary
- Cliniques Universitaires Saint-Luc — Woluwe-Saint-Lambert, Belgium
- Gabrail Cancer Center — Canton, Ohio, United States
- Praxisklinik fur Hamatologie und Onkologie — Koblenz, Germany
- Marien Hospital Duesseldorf — Düsseldorf, Germany
- Ohio State University — Columbus, Ohio, United States
- Markhot Ferenc Oktatokorhaz es Rendelointezet — Eger, Hungary
- CHU de Nice - Hopital L' Archet II — Nice, France
Full record on ClinicalTrials.gov
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