COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis
Completed · Phase 3 · Has a placebo group
Conditions studied: Covid19
In brief
A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge
Key facts
- Study ID
- NCT04650087
- Run by
- Thomas L. Ortel
- People needed
- 1291
- Starts
- 2021-02-15
- Expected to finish
- 2022-09-23
- Last updated by the study team
- 2025-02-25
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- • Age ≥ 18 years
- PCR-positive COVID-19 infection
- Hospitalized for two or more days
You may not qualify if…
- Pre-existing indication for anticoagulation (e.g., pulmonary embolism or deep vein thrombosis; atrial fibrillation; mechanical cardiac valve)
- Contraindication to antithrombotic therapy (e.g., known bleeding within the last 30 days requiring emergency room presentation or hospitalization; major surgery within 14 days; ischemic stroke, intracranial bleed or neurosurgery within 3 months.
- Platelet count < 50,000/mcL
- Hemoglobin <8 gm/dL
- Renal insufficiency (eGFR < 30 mL/min/1.73 m2)
- Pregnancy
- Prison inmate
- Life expectancy less than 90 days
- Unwilling or unable to provide informed consent/unwilling or unable to complete the study protocol
- Dual antiplatelet therapy that cannot be discontinued
- Concomitant need for strong inducers/inhibitors of p-gp or CYP3A4
Where it is running
- Dignity Health-St Josephs — Phoenix, Arizona, United States
- Central Arkansas Veterans Health Care System — Little Rock, Arkansas, United States
- University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Stanford University School of Medicine — Palo Alto, California, United States
- UCSF at Zuckerberg San Francisco General Hospital — San Francisco, California, United States
- New Ananda Medical and Urgent Care, Inc. — South El Monte, California, United States
- Mazur and Statner MD PC — Thousand Oaks, California, United States
- Torrance Medical Center — Torrance, California, United States
- Centura Health Porter Adventist Hospital — Denver, Colorado, United States
- Saint Anthony Hospital — Lakewood, Colorado, United States
- St. Anthony North Health Campus — Westminster, Colorado, United States
- Baycare Hospital — Clearwater, Florida, United States
- Florida Heart Center — Ft. Pierce, Florida, United States
- University of Florida — Gainesville, Florida, United States
- Mount Sinai Medical Center — Miami Beach, Florida, United States
- Tallahassee Memorial HealthCare — Tallahassee, Florida, United States
- James A. Haley Veteran's Hospital — Tampa, Florida, United States
- BayCare Hospital- Winter Haven — Winter Haven, Florida, United States
- Emory University — Atlanta, Georgia, United States
- Medical College of Georgia/Augusta University — Augusta, Georgia, United States
- Savannah Health Services, LLC DBA Memorial Health University Medical Center — Savannah, Georgia, United States
- Queens Medical Center — Honolulu, Hawaii, United States
- Hawaii Pacific Health — Honolulu, Hawaii, United States
- Snake River Research, PLLC — Idaho Falls, Idaho, United States
- Valleywise Health Medical Center — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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