Localizing Epileptic Networks Using MRI and iEEG

Recruiting now · Early Phase 1

Conditions studied: Epilepsy, Epilepsy Intractable, Epilepsy, Temporal Lobe

In brief

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.

Key facts

Study ID

NCT04649008

Run by

University of Pennsylvania

People needed

290

Starts

2021-03-01

Expected to finish

2027-02-28

Last updated by the study team

2026-02-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with medication-refractory epilepsy
• Planned intracranial EEG (IEEG) placement
• Hypothesized to have temporal lobe epilepsy

You may not qualify if…

• Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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