Prospective 4D CTA of BAV Competence

Recruiting now

Conditions studied: Bicuspid

In brief

The study involves annual 4D CTA imaging of the bicuspid aortic valve for a period of 5 years. CTA is often standard of care for BAV patients, but patients in this study will receive a higher radiation dose with a 4D imaging protocol. There may also be patients enrolled in the study who have a 4D CTA for research purposes when a routine CTA is not required for clinical care.

Key facts

Study ID

NCT04645862

Run by

University of Pennsylvania

People needed

60

Starts

2020-12-01

Expected to finish

2027-12-31

Last updated by the study team

2026-02-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 18 years of age
• Documented bicuspid aortic valve identified via clinical imaging (e.g., CT, MRI, or echocardiogram) with minimal calcification at the time of enrollment
• Participant must sign the informed consent form

You may not qualify if…

• Pregnancy (determined by point of care urine pregnancy test)
• Renal failure (estimated Glomerular Filtration Rate (eGFR) < 30), precluding them from receiving intravenous contrast)
• Documentation of previous intravenous contrast allergy (unless they are having a CT with steroid preparation as part of routine clinical care)
• Previous aortic valve replacement

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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