Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
Running, not enrolling · Phase 1/Phase 2
Conditions studied: Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer, Additional Indications Below for Module 4 and 5, Non-small Cell Lung Cancer, Colorectal Cancer, Bladder Cancer, Gastric Cancer, Biliary Cancer, Cervical Cancer, Endometrial Cancer, Small Cell Lung Cancer Only in Module 5
In brief
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid tumors.
Key facts
- Study ID
- NCT04644068
- Run by
- AstraZeneca
- People needed
- 702
- Starts
- 2020-11-12
- Expected to finish
- 2027-05-28
- Last updated by the study team
- 2026-02-19
Who can join
Age: 18 and older, up to 130. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site — Boston, Massachusetts, United States
- Research Site — New York, New York, United States
- Research Site — Oklahoma City, Oklahoma, United States
- Research Site — Houston, Texas, United States
- Research Site — Heidelberg, Australia
- Research Site — Melbourne, Australia
- Research Site — Vancouver, British Columbia, Canada
- Research Site — Toronto, Ontario, Canada
- Research Site — Montreal, Quebec, Canada
- Research Site — Montreal, Quebec, Canada
- Research Site — Beijing, China
- Research Site — Changchun, China
- Research Site — Changsha, China
- Research Site — Chengdu, China
- Research Site — Chongqing, China
- Research Site — Guangzhou, China
- Research Site — Harbin, China
- Research Site — Jining, China
- Research Site — Shandong, China
- Research Site — Shanghai, China
- Research Site — Shanghai, China
- Research Site — Taiyuan, China
- Research Site — Wuhan, China
- Research Site — Xi'an, China
- Research Site — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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