Magnesium for Peroral Endoscopic Myotomy

Completed · Phase 2 · Has a placebo group

Conditions studied: Esophageal Spasm

In brief

Postoperative pain after peroral endoscopic myotomy occurs due to involuntary esophageal smooth muscle spasms. Magnesium has antispasmodic properties as a smooth muscle relaxant. This study hypothesizes that among patients having peroral endoscopic myotomy, magnesium will decrease postoperative esophgeal pain as measured by the esophageal symptoms questionnaire, while decreasing perioperative opioid requirements.

Key facts

Study ID

NCT04638881

Run by

Stanford University

People needed

92

Starts

2020-12-28

Expected to finish

2023-04-13

Last updated by the study team

2024-05-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Planned peroral endoscopic myotomy procedure

You may not qualify if…

• cannot give consent
• patients who are clinically unstable and/or require urgent/emergent intervention
• previous esophageal myotomy
• preexisting hypermagnesemia
• end-stage renal disease
• neuromuscular disease, including but not limited to Guillain-Barre syndrome, myasthenia gravis, congenital myopathy, and muscular dystrophy
• preexisting heart failure
• severe ventricular systolic dysfunction (left or right ventricle)

Where it is running

• Stanford Health Care — Stanford, California, United States

Full record on ClinicalTrials.gov

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