CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

Status unconfirmed · Phase 1

Conditions studied: Lymphoma, Non-Hodgkin, Relapsed Non Hodgkin Lymphoma, Refractory B-Cell Non-Hodgkin Lymphoma, Non Hodgkin Lymphoma, Lymphoma, B Cell Lymphoma, B Cell Non-Hodgkin's Lymphoma

In brief

CB010A is a study evaluating safety, emerging efficacy, pharmacokinetics and immunogenicity of CB-010 in adults with relapsed/refractory B cell non-Hodgkin lymphoma after lymphodepletion consisting of cyclophosphamide and fludarabine.

Key facts

Study ID

NCT04637763

Run by

Caribou Biosciences, Inc.

People needed

72

Starts

2021-05-26

Expected to finish

2025-09-01

Last updated by the study team

2025-03-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age greater than or equal to 18 at the time of enrollment
• Documented diagnosis of relapsed or refractory non-Hodgkin lymphoma after prior standard of care
• Eastern Cooperative Oncology Group performance status 0 or 1
• Adequate hematologic, renal, liver, cardiac and pulmonary organ function

You may not qualify if…

• Prior therapy with an anti-CD19 targeting agent
• Active or chronic graft versus host disease requiring therapy
• Prior allogeneic stem cell transplantation
• Central nervous system (CNS) lymphoma, prior CNS malignancy
• Prior seizure disorder, cerebrovascular ischemia, dementia, cerebellar disease or autoimmune disease with CNS involvement.
• Primary immunodeficiency
• Current or expected need for systemic corticosteroid therapy
• Current thyroid disorder. Hypothyroidism controlled with stable hormone replacement is permitted
• Other malignancy within 2 years of study entry, except curatively treated malignancies or malignancies with low risk of recurrence
• Unwillingness to follow extended safety monitoring

Where it is running

• The Sheba Fund for Health Services and Research (R.A.) — Tel Litwinsky, Israel (enrolling)
• Banner MD Anderson Cancer Center — Gilbert, Arizona, United States (enrolling)
• HonorHealth — Scottsdale, Arizona, United States (enrolling)
• University of Arizona Cancer Center — Tucson, Arizona, United States (enrolling)
• University of Arkansas — Little Rock, Arkansas, United States (enrolling)
• University of California San Diego Moores Cancer Center — La Jolla, California, United States (enrolling)
• University of Southern California, Norris Comprehensive Cancer Center — Los Angeles, California, United States (enrolling)
• Chao Family Comprehensive Cancer Center/University of California Irvine — Orange, California, United States (enrolling)
• Advent Health — Orlando, Florida, United States (enrolling)
• Bone and Marrow Transplant Group of Georgia — Atlanta, Georgia, United States (enrolling)
• Georgia Cancer Center at Augusta University — Augusta, Georgia, United States (enrolling)
• Holden Comprehensive Cancer Center at the University of Iowa — Iowa City, Iowa, United States (enrolling)
• University of Kentucky Markey Cancer — Lexington, Kentucky, United States (enrolling)
• Norton Cancer Institute — Louisville, Kentucky, United States (enrolling)
• Tufts Medical Center — Boston, Massachusetts, United States (enrolling)
• Hackensack Medical Center — Hackensack, New Jersey, United States (enrolling)
• Atlantic Health System — Morristown, New Jersey, United States (enrolling)
• Nyu Langone Health — New York, New York, United States (enrolling)
• Montefiore Medical Center — The Bronx, New York, United States (enrolling)
• Oncology Hematology Care — Cincinnati, Ohio, United States (enrolling)
• Hadassah Medical Center — Jerusalem, Israel (enrolling)
• Rabin Medical Center — Petah Tikva, Israel (enrolling)
• Tel Aviv Medical Center — Tel Aviv, Israel (enrolling)
• Oregon Health & Science University — Portland, Oregon, United States (enrolling)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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