Superior Vena Cava Reconstruction in Patients on Hemodialysis
Completed
Conditions studied: Superior Vena Cava Syndrome
In brief
The treatment objective for patients with SVC syndrome secondary to both malignant and benign etiologies is to reduce the elevated central venous pressures.1 However, the strategies are contingent upon the underlying disease process. Thus the management of SVC syndrome ranges from medical or supportive care to surgical bypass,3 and it is important for physicians to understand the varied treatment modalities of this potentially life-threatening disease.17 Fortunately, the overwhelming majority of patients with SVC syndrome secondary to benign causes develop a physiologic compensation for the obstruction that can be treated with anticoagulation and endovascular modalities. Intervention for symptomatic relief may not be required.1 An endovascular approach is the current standard of care to relieve SVC obstruction due to malignancy to obtain prompt relief of the rapidly emerging symptoms and improve quality of life,3 keeping in mind the short life expectancy of these patients. The role of endovascular therapy in SVC syndrome of nonmalignant etiology is undecided because the long-term durability of this treatment method remains to be assessed.
Key facts
- Study ID
- NCT04637334
- Run by
- Methodist Health System
- People needed
- 45
- Starts
- 2014-09-13
- Expected to finish
- 2022-05-06
- Last updated by the study team
- 2026-03-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Presence of SVC syndrome or SVC occlusion
- Presence of ESRD on hemodialysis
- Presence of upper extremity or neck access, either catheter or surgical fistula
- Patients who have received endovenous or open bypass reconstruction of the SVC secondary to SVC syndrome or SVC occlusion
You may not qualify if…
- Patients who have not undergone endovenous or open bypass reconstruction of the SVC secondary to SVC syndrome or SVC occlusion
Where it is running
- Methodist Dallas Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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