Prevalence and Significance of ATTR Aortic Valve Amyloidosis in Degenerative Aortic Stenosis

Recruiting now · Not applicable

Conditions studied: Amyloidosis

In brief

Cardiac amyloidosis is a restrictive cardiomyopathy with a potentially severe prognosis that can be life-threatening. It is linked in the vast majority of cases to a light chain deposition of immunoglobulin or transthyretin. Although myocardial involvement is predominant, other locations are possible: the atrioventricular conduction system, coronary arteries and valve leaflets. In systematic histological analyzes, deposits of amyloidosis infiltrating the aortic valve have been reported with a frequency of up to 74% for degenerative RA. The nature of these deposits has never been established because the immunostaining carried out all remained negative, probably due to decalcification prior to cutting. Currently, these deposits are considered to be local degenerative phenomena without clinical repercussions. However, the use of bone scintigraphy has shown a high prevalence, between 14 and 16%, of ATTR cardiac amyloidosis in patients with severe RA. The diagnosis of ATTR amyloidosis has been proven histologically in a few patients. Sequencing of the TTR gene has shown that they are mainly wild forms. In fact, the prevalence of transthyretin mutations in our local cohort is 20%. The objective of this study is to determine by proteomic analysis based on mass spectrometry, the prevalence of ATTR aortic valve amyloidosis in patients undergoing surgical valve replacement for degenerative aortic stenosis.

Key facts

Study ID

NCT04636684

Run by

University Hospital, Toulouse

People needed

100

Starts

2020-12-01

Expected to finish

2027-12-31

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient over 18 years old
• Degenerative aortic stenosis
• Aortic valve replacement surgery
• Signature of the informed consent form

You may not qualify if…

• Non-degenerative aortic stenosis: bicuspid, rheumatic disease, aortic regurgitation
• Persons under a system of legal protection for adults (guardianship, curatorship, etc.)
• Pregnant women

Where it is running

• university hospital center Toulouse — Toulouse, France (enrolling)

Full record on ClinicalTrials.gov

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